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KMID : 0829220200440040103
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Korean Journal of Oral and Maxillofacial Pathology
2020 Volume.44 No. 4 p.103 ~ p.112
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Dysosteogenesis in the Mandibular Bone of SAMP1/Klotho-Deficient Mice
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Yook Jong-In
Toan Nguyen Khanh
Seo Yo-Seob
Yu Sang-Joun
Ahn Sang-Gun
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Abstract
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Aging is a physiological change that leads to a decline in biological functions from metabolic stress. To investigate the effect of aging on mandibular bone formation, we created SAMP1/Klotho-deficient mice and performed micro-computed tomography (micro-CT) and histology analyses in 4-or 8 week-old SAMP1/kl -/- mice. SAMP1/kl -/- mice exhibited extensive inflammation, tissue calcification, and abnormal mandibular bone development. Using micro-CT analysis, SAMP1/kl -/- mice displayed a loss of incisor roots and irregular dentinal tubule formation, as well as calcification within the pulp root canal. Furthermore, the mandibular ramus showed extensive ground glass appearance in SAMP1/kl -/- mice. In histological analysis, we found calcified skeletal structures and dysplastic bone formation in SAMP1/kl -/- mice. These results provide an understanding of the pathologic alterations of aging-related mandibular bone. SAMP1/kl -/- mice may serve as a novel model for dysosteogenesis in mandibular bone development.
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KEYWORD
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SAMP1/ Klotho, Aging, Dysosteogenesis, Mandibular bone, Bone development
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